首页   按字顺浏览 期刊浏览 卷期浏览 The synthesis of [1′,3′‐3H]4‐(4′‐azido‐5′,6′,7′,8′‐tetrahydro‐5′,5′,8′,8′‐tetramethyl‐2...
The synthesis of [1′,3′‐3H]4‐(4′‐azido‐5′,6′,7′,8′‐tetrahydro‐5′,5′,8′,8′‐tetramethyl‐2′‐anthracenyl)benzoic acid as a probe of the retinoic acid receptor

 

作者: Marcia I. Dawson,   Peter D. Hobbs,   Albert Dorsky,   Hiromi Morimoto,  

 

期刊: Journal of Labelled Compounds and Radiopharmaceuticals  （WILEY Available online 1990）
卷期: Volume 28, issue 1  

页码: 89-98

 

ISSN:0362-4803

 

年代: 1990

 

DOI:10.1002/jlcr.2580280111

 

出版商: John Wiley&Sons, Ltd.

 

关键词: [1′,3′‐3H]4‐(4′‐azido‐5′,6′,7′,8′‐tetrahydro‐5′,5′,8′,8′‐tetramethyl‐2′‐anthracenyl)benzoic acid;photoaffinity probe;retinoid;cellular retinoic acid‐binding protein

 

数据来源: WILEY

 

摘要:

AbstractThe synthesis of [1′,3′‐3H]4‐(4′‐azido‐5′,6′,7′,8′‐tetrahydro‐5′,5′,8′,8′‐tetramethyl ‐2′‐anthracenyl)benzoic acid is described. This retinoid was designed as a photoaffinity probe of the receptor sites of cellular retinoic acid‐binding protein and the nuclear retinoic acid receptor protein. The [3H]azidoretinoid was prepared from 1,2,3,4‐tetrahydro‐1,1,4,4‐tetramethyl‐7‐(4‐methylphenyl)‐5‐nitroanthracene in five steps in 15% yield (89% radiochemical purity by HPLC).1H and3H NMR

 

点击下载:  PDF (483KB)



返 回