Clinical Pharmacokinetics of Ketoprofen After Single Intravenous Administration as a Bolus or Infusion
作者:
Danièle Debruyne,
Bruno Hurault de Ligny,
Jean-Philippe Ryckelynck,
Françoise Albessard,
Maurice Moulin,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1987)
卷期:
Volume 12,
issue 3
页码: 214-221
ISSN:0312-5963
年代: 1987
出版商: ADIS
数据来源: ADIS
摘要:
The pharmacokinetics of ketoprofen were evaluated in 29 patients suffering from acute renal colic following a single intravenous administration as a bolus or short infusion (1.5 and 2 hours), and after a loading dose and a 24-hour infusion. Serum concentrations of ketoprofen were measured by high pressure liquid chromatography. The mean (± SD) values of clinical parameters were as follows: distribution half-life = 0.34 ± 0.19h; elimination half-life = 2.05 ± 0.58h; kel= 0.968 ± 0.282h−1; k21= 0.943 ± 0.425 h−1; k12= 1.004 ± 0.708 h−1; volume of central compartment = 5.58 ± 1.67L; volume of tissue compartment = 5.14 ± 2.12L; plasma clearance = 5.10 ± 1.14L/h. These results concur with previously published data obtained after oral or intramuscular administration.According to clinical observations, administration of a ketoprofen bolus suppressed pain within 5 to 30 minutes; the administration of a loading dose and a 24-hour infusion is almost never followed by a recurrence of pain, and this regimen was proposed as the dosage schedule of ketoprofen to treat renal colic.
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