The Biochemical Basis for the Antagonism hy BOMT of the Effects of Dihydrotesterone on the Rat Ventral Prostate Gland
作者:
F.R. Mangan,
W.I.P. Mainwaring,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1971)
卷期:
Volume 2,
issue 1-6
页码: 300-304
ISSN:0378-7346
年代: 1971
DOI:10.1159/000301871
出版商: S. Karger AG
关键词: Antiandrogenie actionof BOMT on rat ventral prostate gland
数据来源: Karger
摘要:
BOMT has been found to suppress nuclear binding of DHT in prostate gland in vitro and to compete with DHT for the specific high-affinity binding sites for DHT in the prostate cytoplasm. BOMT reduces the transfer of DHT into prostate chromatin in a reconstituted cell free system and antagonises the stimulation by testosterone of prostate RNA polymerase activity on injection in vivo. owever BOMT was found to have no effect on the 5α-reductase activity of rat prostate minces in vitro. It is suggested that the anti-androgenic properties of BOMT on the rat prostate gland can be explained by its competition for DHT binding sites within the gland.
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