Co-Expression of ras p21 and Epidermal Growth Factor Receptor during Various Stages of Tumour Progression in Oral Mucosa
作者:
S. Kannan,
Prabha Balaram,
Jagadeesh Chandran,
Radhakrishna Pillai,
Babu Mathew,
Krishnan Nair,
期刊:
Tumor Biology
(Karger Available online 1994)
卷期:
Volume 15,
issue 2
页码: 73-81
ISSN:1010-4283
年代: 1994
DOI:10.1159/000217877
出版商: S. Karger AG
关键词: Epidermal growth factor receptor;Immunohistochemistry;Ras p21;Leucoplakia;Oral cancer
数据来源: Karger
摘要:
Ras p21 and epidermal growth factor receptor (EGFR) have commonly been implicated in a variety of malignancies. The present study immunohistochemically analysed the relationship between the expression of ras p21 and EGFR in normal, premalignant and malignant lesions of the oral mucosa. Except for normal mucosa, all other lesions showed a more or less similar expression pattern of both ras p21 and EGFR. It was also observed that the expression of both proteins was mostly confined to the basal or basaloid cells of the leucoplakia and carcinoma lesions, respectively. Normal keratinizing type mucosa showed expression of ras p21 and EGFR in the basal and lower spinal cells. However, in non-keratinizing mucosa the expression of ras p21 was totally negative while EGFR was restricted to the basal cells. Statistical analysis revealed a good correlation between the expression of ras p21 and EGFR with the various histological stages of tumour progression. The presence of these proteins in immature dividing cells of premalignant and malignant lesions thus emphasizes their relationship with cell proliferation.
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