Effect of Portal Arterialization on Hepatic Cytochrome P-450 in Rats with Portacaval Shunt
作者:
J.C. Pector,
S. Verbeustel,
J.P. Lambilliotte,
期刊:
Digestion
(Karger Available online 1975)
卷期:
Volume 12,
issue 3
页码: 144-151
ISSN:0012-2823
年代: 1975
DOI:10.1159/000197669
出版商: S. Karger AG
关键词: Clearance;Cytochrome P-450;Enzyme induction;Liver circulation;Liver function test;Portacaval anastomosis;Phenobarbital;Rats
数据来源: Karger
摘要:
Fractional clearance of colloidal gold particles (k), liver weight and hepatic cytochrome P-450 were measured in rats with portacaval shunt and in rats with portacaval shunt plus arterialization of the hepatic stump of the portal vein. The effects of enzyme induction by phenobarbital was studied in both groups. Total arterialization of the liver provides a probably normal hepatic blood flow and seems to protect the liver from post-shunt atrophy. Nevertheless, in both arterialized and shunted rats, the cytochrome P-450 concentration was significantly lower than in controls. The same results were obtained after treatment by phenobarbital. These findings suggest that normal hepatic blood flow and oxygen supply are not the main determinant of a normal activity of the hepatic microsomal bio transformation system. Substances present in portal blood would probably be necessary in maintaining hepatic cytochrome P-450 level.
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