Directed metalation of pyridinesulphonamides. Synthesis of pyridine‐fused isothiazoles and 1,2‐oxathioles
作者:
Babajide I. Alo,
Oluwole B. Familoni,
Francis Marsais,
Guy Queguiner,
期刊:
Journal of Heterocyclic Chemistry
(WILEY Available online 1992)
卷期:
Volume 29,
issue 1
页码: 61-64
ISSN:0022-152X
年代: 1992
DOI:10.1002/jhet.5570290109
出版商: Wiley‐Blackwell
数据来源: WILEY
摘要:
Abstract4‐Lithio‐N‐t‐butylpyridine‐3‐sulphonamide reacted with benzophenone and carbon dioxide respectively to give the corresponding intermediates which on appropriate treatment gave isothiazolo[5,4‐c]pyridin‐3‐one 1,1‐dioxides. Metalation of 2‐ and 4‐(N,N‐dialkylaminosulphonyl)pyridines with lithium diisopropylamide (LDA) gave anions which reacted with benzophenone to give carbinols which thermally cyclised to 1,2‐oxathiolo[3,4‐b]pyridine and 1,2‐oxathi
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