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Postnatal Sequential Changes in Islet Morphology and Insulin Secretion of Normal Hamsters

 

作者: L. Massa,   H. Zotto,   C. Gómez Dumm,   J. Gagliardino,  

 

期刊: Pancreas  (OVID Available online 1997)
卷期: Volume 14, issue 1  

页码: 58-64

 

ISSN:0885-3177

 

年代: 1997

 

出版商: OVID

 

关键词: Islets;Insulin secretion;Pancreas development;Hamsters;Islet cell populations

 

数据来源: OVID

 

摘要:

We have studied the postnatal development of the endocrine pancreas from normal female Syrian golden hamsters 1, 8, and 24 weeks of age. The observations were made by (a) analysis of insulin secretion in response to glucose using isolated pancreatic islets and (b) identification and quantitation of insulin-, glucagon-, somatostatin-, and pancreatic polypeptide-secreting cells. Glucose-induced insulin secretion showed typical dose-response curves. However, whereas in 24-week-old animals maximal secretion was already present with 8 mMglucose, in younger hamsters such a response was attained only with 20 mMglucose. The volume density of the endocrine pancreas and the number of islets were increased in 1-week-old hamsters compared to the older animals. The islet volume average in 8-week-old hamsters was almost three times higher than that measured in 1-week-old animals. However, the proportion and size of each cell type in the islets did not present significant differences among the groups studied. Our results show that, in hamsters, the endocrine pancreas reaches the adult general characteristics late afterbirth. Furthermore, the definite morphological pattern is attained far earlier than the secretory response. These observations provide basic information for further studies regarding the mechanisms and factors that control both the growth and the differentiation of endocrine cell populations as well as glucose-induced insulin secretion in a simple experimental model.

 

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