Atrium and Paroxetine-Related Severe Hepatitis
作者:
Jean-François Cadranel,
Vincent Di Martino,
Alain Cazier,
Véronique Pras,
Claude Bachmeyer,
Paul Olympio,
Alain Gonzenbach,
Ali Mofredj,
Pierre Coutarel,
Bruno Devergie,
Michel Biour,
期刊:
Journal of Clinical Gastroenterology
(OVID Available online 1999)
卷期:
Volume 28,
issue 1
页码: 52-55
ISSN:0192-0790
年代: 1999
出版商: OVID
关键词: Atrium;Paroxetine;Hepatotoxicity;Severe hepatitis;Microsomes
数据来源: OVID
摘要:
Two cases of severe hepatitis in young women using Atrium and paroxetine are presented. Both patients presented jaundice, marked increase in aminotransferases activities, and pronounced prolongation in prothrombin time. In both cases, liver biopsy specimen examination revealed lesions compatible with drug-related injury. Other causes of hepatic injury were reasonably ruled out by complete careful screening. Outcome was marked by rapid complete recovery in one case and by slow recovery in the other. We suggest that simultaneous treatment with Atrium and paroxetine could increase each of these drugs' hepatotoxicity.
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