The mGlu receptor ligand (S)‐4C3HPG protects neurons after global ischaemia in gerbils
作者:
Petra Henrich-Noack,
Christopher Hatton,
Klaus Reymann,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 6
页码: 985-988
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Cerebral ischaemia;Gerbil;Hippocampus;Neuroprotection;(S)-4C3HPG;mGlu receptors
数据来源: OVID
摘要:
(S)-4-Carboxy-3-Hydroxy-Phenylglycine [(S)-4C3HPG] is a potent competitive antagonist at the metabotropic glutamate receptor 1 subtype (mGlu1 receptor) and an agonist at mGlu2/3 receptor. We evaluated histologically the effect of this compound on transient global ischaemia in gerbils and observed pronounced neuroprotection in the CA1 layer of the hippocampus. When (S)-4C3HPG (1 μM) was administered intra-cerebroventricularly (i.c.v.) 20 min before clamping both common carotid arteries neuronal density was comparable with that in sham-operated animals. A single injection (1 μM) 65 min after ischaemia also significantly reduced neuronal damage. The results suggest that metabotropic glutamate receptors play a role in the deleterious cascade which leads to neuronal damage of pyramidal cells in the CA1 layer of the hippocampus after transient global ischaemia.
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