Acute Renovascular Hypertension in Conscious DogsInteraction of the Renin‐Angiotensin System and Sympathetic Nervous System in Systemic Hemodynamics and Regional Blood Flow Responses
作者:
HARALAMBOS GAVRAS,
CHANG-SENG LIANG,
期刊:
Circulation Research
(OVID Available online 1980)
卷期:
Volume 47,
issue 3
页码: 356-365
ISSN:0009-7330
年代: 1980
出版商: OVID
数据来源: OVID
摘要:
The effects of acute renovascular hypertension on the sympathetic nervous system, regional blood flow and cardiac function were studied in conscious dogs submitted to renal artery occlusion by inflation of a cuff implanted previously around one renal artery. We then compared the alterations in plasma renin and catecholamine levels and in the various hemodynamic parameters induced by those maneuvers in intact dogs, to those in dogs pretreated with α-and β-adrenergic receptor blockers. Subsequently, the converting enzyme inhibitor teprotide was administered to inhibit angiotensin formation in both experiments. Our results suggest that both the renin-angiotensin system and the sympathetic system contribute to the rise in blood pressure. The hemodynamic changes and alterations in regional blood flows accompanying this acute hypertension appear to be due mostly to the increase in plasma angiotensin, since prior adrenoceptor blockade only attenuated their magnitude but did not alter their direction. However, angiotensin-induced coronary vasoconstriction was observed only in adrenergically blocked but not intact animals, probably because of the protective effect of baroreceptor-mediated reflex sympathetic coronary vasodilation. Circ Res 47: 356-365, 1980
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