Effect of Serotonin-Releasing Drugs on Serum Corticosterone Concentration in Rats
作者:
Ray W. Fuller,
Harold . Snoddy,
期刊:
Neuroendocrinology
(Karger Available online 1980)
卷期:
Volume 31,
issue 2
页码: 96-100
ISSN:0028-3835
年代: 1980
DOI:10.1159/000123057
出版商: S. Karger AG
关键词: Corticosterone;Brain serotonin;p-Chloroamphetamine;Fenfluramine
数据来源: Karger
摘要:
(± )pChloroamphetamine hydrochloride, at doses of 1–8 mg/kg i.p. in rats, caused a dose-related increase in serum corticosterone concentration. The increase occurred rapidly, within 30 min, and was over within 4 h. Evidence that the increase was mediated by serotonin release consisted of the following findings: (1) a similar increase did not occur with (±)o-chloroamphetamine or (±)p-chloro-α-methylbenzylamine, analogs of p-chloroamphetamine lacking its ability to deplete serotonin; (2) the increase was prevented by prior treatment with p-chlorophenylalanine, which reduced the brain stores of serotonin available for release by p-chloroamphetamine; (3) the increase was prevented by prior treatment with fluoxetine, an inhibitor of the uptake pump on serotonin neurons, which blocks serotonin release by p-chloroamphetamine, and (4) the increase was mimicked by fenfluramine and norfenfluramine, agents known to release brain serotonin in a manner similar to the action of p-chloroamphetamine. These findings strengthen earlier evidence that brain serotonin neurons have a stimulatory influence on pituitary-adrenocortical function in
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