Diclofenac, a Nonsteroidal Anti-Inflammatory Drug, Decreases Proteinuria in Some Glomerular Diseases: A Controlled Study
作者:
Jérôme Laurent,
Dominique Belghiti,
Charles Bruneau,
Gilbert Lagrue,
期刊:
American Journal of Nephrology
(Karger Available online 1987)
卷期:
Volume 7,
issue 3
页码: 198-202
ISSN:0250-8095
年代: 1987
DOI:10.1159/000167463
出版商: S. Karger AG
关键词: Nonsteroidal anti-inflammatory drugs;Proteinuria;Diclofenac;Glomerulonephritis
数据来源: Karger
摘要:
Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) was first used in glomerulonephritis (GN) in 1966 but its efficiency is still debated. We studied the antiproteinuric effect of such a treatment in a double-blind study. 29 GN patients with normal renal function (17 membranoproliferative GN, 12 IgA GN) were randomly assigned to receive 100 mg/day of diclofenac or placebo for at least 2 months. There was a significant antiproteinuric effect of diclofenac versus placebo with a fall of 70% in the diclofenac group versus 6 % in the placebo group (p < 0.001 with the Mann-Whitney test). The median was 3 mg/min at onset and 2.45 mg/min after 2 months treatment with the placebo. In the diclofenac group, it was 2.2 and 0.95 mg/min, respectively (p < 0.01). Diclofenac did not significantly increase creatinine levels. Gastric irritation was noted only once. This study establishes the short-term antiproteinuric ation of diclofenac. Whether this action affets the final outcome is not yet determined.
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