On the Relationship between the Activity of Acetylation, Growth of Experimental Tumors and Efficacy of their Suppression by Hydrazine Sulphate
作者:
V.M. Dilman,
V.N. Anisimov,
A.I. Kolosov,
L.N. Bulovskaya,
期刊:
Oncology
(Karger Available online 1976)
卷期:
Volume 33,
issue 5-6
页码: 219-221
ISSN:0030-2414
年代: 1976
DOI:10.1159/000225149
出版商: S. Karger AG
关键词: Acetylation;Tumors;Hydrazine sulphate
数据来源: Karger
摘要:
The growth of experimental tumors was found to involve an intensification of acetylation of sulphadimidine. Inhibition of carcinosarcoma Walker-256 by 88% and sarcoma-180 by 36% on treatment with 60 mg/kg body weight of hydrazine sulphate was followed by decreases in the rate of acetylation of 39.4 and 29.4%, respectively. When treatment failed to suppress tumor growth (sarcoma-45), acetylation level showed no decrease. The results point to a correlation between growth of tumors and their inhibition on the one hand and the level of acetylation on the other.
点击下载:
PDF
(1505KB)
返 回