Effects of dopamine on cerebral circulation and oxygen metabolism in endotoxic shockan experimental study in dogs
作者:
B. EKSTRÖM-JODAL,
L. LARSSON,
期刊:
Critical Care Medicine
(OVID Available online 1982)
卷期:
Volume 10,
issue 6
页码: 375-377
ISSN:0090-3493
年代: 1982
出版商: OVID
数据来源: OVID
摘要:
Experimental endotoxic shock in normocapnic dogs decreases cerebral blood flow (CBF) and increases cerebral metabolic rate of oxygen (CMRO2). In 6 animals, an iv injection of 1.0–1.5 mg/kg ofEscherichia coliendotoxin was followed by iv infusion of dopamine HC1 at a rate of 3–24 μg/kg · min. Doses of only 5 fig/kg · min maximally increased both CBF and CMRO2. There were no significant changes in cardiac output and whole body oxygen consumption. Mean aortic pressure and mean pulmonary artery pressure increased slightly after doses of 20 μg/kg · min. Results indicate that damage to the blood-brain barrier (BBB) after endotoxin administration allowed circulating monoamines to directly influence cerebral metabolism.
点击下载:
PDF
(252KB)
返 回