LIPOSOME MICROENCAPSULATIONS WITHOUT USING ANY ORGANIC SOLVENT
作者:
S. Zheng,
H. Alkan-Onyuksel,
R.L. Beissinger,
D.T. Wasan,
期刊:
Journal of Dispersion Science and Technology
(Taylor Available online 1999)
卷期:
Volume 20,
issue 4
页码: 1189-1203
ISSN:0193-2691
年代: 1999
DOI:10.1080/01932699908943844
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Liposomes are microscopic vesicles composed of phospholipid bilayers surrounding discrete aqueous compartment. Eventhough phospholipid bilayers are formed spontaneously in water, their conventional preparation methods involve either organic solvents or detergent molecules. Organic solvents may create a serious safety problem during liposome manufacturing especially on a large scale and can cause denaturation of proteins and affect the membrane properties. Liposomes are very promising carriers for protein drugs which have aroused great interests in the field of pharmaceutics in these recent years.
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