Rubella Virus Strains Show No Major Antigenic Differences
作者:
Jennifer M. Best,
Aileen Thomson,
Julia Rey Nores,
Siobhan O’Shea,
J.E. Banatvala,
期刊:
Intervirology
(Karger Available online 1992)
卷期:
Volume 34,
issue 3
页码: 164-168
ISSN:0300-5526
年代: 1992
DOI:10.1159/000150277
出版商: S. Karger AG
关键词: Rubella virus;Antigenic differences;Monoclonal antibodies
数据来源: Karger
摘要:
To determine whether antigenic differences occur among rubella virus strains, five wild-type strains of rubella virus isolated in the UK, the USA, and in Japan between 1964 and 1987 and four attenuated vaccine strains were compared employing a panel of 28 monoclonal antibodies in neutralization, haemag-glutination-inhibition, enzyme immunoassay, and indirect immunofluorescence assays. No antigenic differences were detected which confirms that rubella vaccines will protect against circulating strains and that rubella antigens used in serological tests for screening and diagnosis will detect antibodies induced by all strains.
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