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Drug redistribution and mean transit time concepts for nonlinear pharmacokinetic systems

 

作者: Haiyung Cheng,   William J. Jusko,  

 

期刊: Biopharmaceutics&Drug Disposition  （WILEY Available online 1991）
卷期: Volume 12, issue 1  

页码: 73-79

 

ISSN:0142-2782

 

年代: 1991

 

DOI:10.1002/bdd.2510120108

 

出版商: John Wiley&Sons, Ltd.

 

关键词: Drug redistribution;Mean number of cycles through the peripheral system;Mean transit time;Concentration‐average clearance;Disposition decomposition analysis

 

数据来源: WILEY

 

摘要:

AbstractEquations for the mean number of cycles through the peripheral system (R) and the mean transit time through the central compartment (MTTc) are derived for intravenous drugs with linear distribution and linear or nonlinear central elimination. ThisRis a function of distribution clearance (CLD), dose, and area under the plasma concentration–time curve (AUC). TheMTTcis a function of the central volume of distribution, CLD, dose, and AUC. The application of the proposed calculations ofRandMTTcwas illustrated by computer simulation

 

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