Pharmacokinetic Principles of Antineoplastic Drug Therapy
作者:
LARRY M. ALLEN,
期刊:
The Journal of Clinical Pharmacology
(WILEY Available online 1983)
卷期:
Volume 23,
issue 2‐3
页码: 71-81
ISSN:0091-2700
年代: 1983
DOI:10.1002/j.1552-4604.1983.tb02707.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Abstract:Determinants of host—drug interaction comprise a complex of potentially variable factors. The complexity of this variability compromises the forecasting of favorable response in individual patients given standard therapy. Substantial success with current forms of chemotherapy may require that biochemical, pharmacologic, and clinical profiles be established for each cancer patient whereby the use of drug and drug combination can be rationally applied. The significance of evaluating clinical pharmacokinetic parameters in patients with cancer is placed in perspective with other factors relevant to individual drug respons
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