Recurrent Genital Infection in the Guinea Pig: Differences between Herpes Simplex Types 1 and 2
作者:
Marie L. Landry,
David Myerson,
Cathy Bull,
期刊:
Intervirology
(Karger Available online 1992)
卷期:
Volume 34,
issue 4
页码: 169-179
ISSN:0300-5526
年代: 1992
DOI:10.1159/000150279
出版商: S. Karger AG
关键词: Genital heφes recurrence;Heφes simplex virus
数据来源: Karger
摘要:
Recurrence rates of genital infections are significantly higher for heφes simplex virus (HSV) type 2 than HSV type 1. Reasons for this difference are not known. In this report, multiple strains of HSV-1 and HSV-2 were evaluated in the guinea-pig model. HSV-2 strains showed significantly higher genital lesion recurrence than HSV-1, including HSV-1 McKrae strain which is highly recurrent in ocular infections. HSV-2 strains were also associated with more frequent asymptomatic vaginal virus shedding. Further study showed that HSV-1 strains replicated as well as HSV-2 in both the genital tract and the nervous system during acute infection. In addition, no difference was detected between HSV-1 and HSV-2 in nervous system latency. Thus, a number of possible explanations for the observed difference in genital heφes recurrence rates were examined and exclude
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