Systemic lupus erythematosus (SLE) is a complicated immune complex disorder most commonly occurring in women of childbearing years and often diagnosed during adolescence. This article focuses on the female adolescent with SLE.‘The epidemiology, etiology, immunology, symptomatology, diagnosis, and treatment of the disease are reviewed. The possible effects of SLE on three components of adolescent development are examined: the development of body-image, the establishment of independence and future goals, and identity formation. The suggestion is made to educate the adolescent and her family about the disease, including immunology, symptoms, preventive measures. and treatment.I wish to acknowledge Barbara Brodie, Jane Baht, and Carolyn M. Brunner, all of the University of Virginia for their guidance and help in the preparation of this article.