Relationship between vapor exposure and urinary metabolite excretion among workers exposed to trichloroethylene
作者:
Osamu Inoue,
Kazunori Seiji,
Toshio Kawai,
Chui Jin,
Yu‐Tang Liu,
Zhen Chen,
Shi‐Xiong Cai,
Song‐Nian Yin,
Gui‐Lan Li,
Haruo Nakatsuka,
Takao Watanabe,
Masayuki Ikeda,
期刊:
American Journal of Industrial Medicine
(WILEY Available online 1989)
卷期:
Volume 15,
issue 1
页码: 103-110
ISSN:0271-3586
年代: 1989
DOI:10.1002/ajim.4700150111
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: diffusive sampling;ethnic difference;total trichloro‐compounds;trichloroacetic acid;trichloroethanol
数据来源: WILEY
摘要:
AbstractThe exposure—excretion relationship was investigated in 140 trichloroethylene (TRI)‐exposed workers and 114 nonexposed controls. The time‐weighted average intensity of exposure to TRI during the shift as measured by the diffusive sampling method was compared with metabolite levels in the urine collected at the end of the shift in the second half of a working week, when the urinary metabolite levels are expected to reach a maximum. The TRI levels in breathing zone air of the exposed workers were mostly below 50 ppm. The urinary metabolite levels (i.e., total trichloro‐compounds, trichloroethanol, and trichloroacetic acid) increased as a linear function of the TRI exposure. The relationship between the two exposure indicators was statistically significant in men, women, and both combined. The cross‐sectional balance study at the end of the shift revealed that about 4% of TRI absorbed will be excreted at the end of the shift, in agreement with the long biological half‐life of this chlorinated hydrocarbon solvent. A possible ethnic difference in the metabolism of TRI i
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