Background.We report an unusual type of corneal change in some communities mesoendemic for onchocerciasis in Kaduna State of Northern Nigeria.Methods.Thirty-four villages with an overall average microfilarial skin snip positivity rate of 71% and a total population of about 10,000 were included in a controlled trial of ivermectin for onchocerciasis. Detailed slit lamp examination of 806 persons within this population revealed at least 27 individuals with these lesions. There were 11 women and 16 men, aged between 5 and 70 years with a mean age of 45 years and a SD of 15 years. Drawings and photographs of 22 of these individuals were available for assessment.Results.The lesions were peripheral, silvery white, and of two main types: the first group's lesions wereflaky, refractile, and crystalline in appearance; the second group's lesions were more cylindrical in outline and were crisscrossed, giving alattice-like pattern. There were indeterminate forms in between these polar topographies. Of the 25 subjects who had skin snips performed, 23 were microfilaria-positive. There was no accompanying inflammation and the posterior segments showed no evidence of crystalline deposits or retinitis pigmentosa, as is found in Bietti's dystrophy. The lesions coexisted with typical sclerosing keratitis in six individuals, and changes noted in the posterior pole of ten individuals were typical of onchocercal chorioretinitis. The evidence for consanguinity was not compelling. Differences between and similarities to Bietti's and Schnyder's crystalline corneal dystrophy, which are known to be composed of cholesterol crystals, are discussed. The lesions are also compared with lattice dystrophy known to be composed of amyloid. These lesions may be related to onchocercal infection.Conclusions.We describe some unusual peripheral corneal changes in individuals living within areas of Northern Nigeria mesoendemic for onchocerciasis. These changes take the form of flaky crystals or lattice within the anterior stroma and are common in middle-aged individuals. This may be related to onchocercal infection.