Regulation of autologous T‐lymphocyte clones onin vitrogrowth of BFU‐e: Enhancing effects of both CD4‐ and CD8‐positive clones
作者:
B. Nielsen,
P. Jessen,
P. Hokland,
期刊:
European Journal of Haematology
(WILEY Available online 1991)
卷期:
Volume 46,
issue 1
页码: 26-32
ISSN:0902-4441
年代: 1991
DOI:10.1111/j.1600-0609.1991.tb00509.x
出版商: Blackwell Publishing Ltd
关键词: erythroid burst‐forming unit (BFU‐e);T lymphocytes;cloned cells
数据来源: WILEY
摘要:
Abstract:In order to characterize the effect of T lymphocytes on thein vitrogrowth of erythroid progenitor cells (EPC), we have optimized an assay for evaluating the influence of autologous T‐ lymphocyte clones on BFU‐e, grown from PBMNCs depleted of T lymphocytes. Testing a large number of T‐lymphocyte clones from 2 individuals we found that, irrespective of immunological phenotype, all clones tested were found to enhance the growth of BFU‐e. Thus, no evidence for a functional dichotomy between CD4+ and CD8+ T lymphocytes was found in this system. The enhancing effect worked across a histocompatibility barrier and was, at least in part, mediated by soluble factors. We therefore conclude that the role of the majority of cloned normal T lymphocytes in the regulation of thein vitrogrowth of EPC is a support
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