Toxicology of sulphiting agents I: Animal studies
作者:
H. P. Til,
V. J. Feron,
期刊:
Food Additives & Contaminants
(Taylor Available online 1992)
卷期:
Volume 9,
issue 5
页码: 587-595
ISSN:0265-203X
年代: 1992
DOI:10.1080/02652039209374112
出版商: Taylor & Francis Group
关键词: sulphiting agents;sodium metabisulphite;oral toxicity;rat;pig;quail;ADI;stored diets;unsaturated fats
数据来源: Taylor
摘要:
Oral toxicity studies of sulphite in animals are briefly reviewed. On the basis of a chronic toxicity/carcinogenicity study of sodium metabisulphite in rats JECFA established an ADI of 0.7 mg SO2/kg using a safety factor of 100. The effects of sodium metabisulphite (1% Na2S2O5) on the composition of semi‐purified rat diets during storage for at least three months have been studied. Under these conditions sulphite induced rancid off‐flavours in diets containing unsaturated fats. The feeding of such stored sulphited‐diets to rats resulted in growth retardation and diminished food efficiency. The extractability of the lipids from these diets was markedly reduced. Extraction with hexane, followed by ethanol extraction did not remove the toxic factor(s). It was suggested that sulphite in stored semi‐purified diets may react with unsaturated fats leading to the formation of polymers of unsaturated fatty acids and/or other toxic substances. It is recommended that special attention is paid to the fatty acid composition of sulphited foods to be stored.
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