Inhibition of Bile Acid and Water Absorption by Phenethylbiguanide in Rat Ileumin vivo
作者:
W.F. Caspary,
H. Lücke,
期刊:
Digestion
(Karger Available online 1975)
卷期:
Volume 12,
issue 3
页码: 179-182
ISSN:0012-2823
年代: 1975
DOI:10.1159/000197672
出版商: S. Karger AG
关键词: Biguanides;Bile acids and salts;Ileum;Intestinal absorption;Rats;Taurocholic acid
数据来源: Karger
摘要:
Since biguanides are known to inhibit hexose and amino acid absorption in vivo and in vitro as well as vitamin B12 absorption the effect of phenethylbiguanide on taurocholate (TC) and water absorption was measured in rat ileum in vivo. Phenethylbiguanide exhibited a time-dependent inhibitory effect on TC- and water absorption. If the bile acid inhibitory effect of biguanides can be found in diabetics on treatment with biguanides it might explain the observed cholesterol-lowering effect of these oral antidiabetic drugs.
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