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Steroid Trimethylsilyl Ethers. Derivative Formation for Compounds with Highly Hindered Hydroxyl Groups

 

作者: N. Sakauchi,   E.C. Horning,  

 

期刊: Analytical Letters  （Taylor Available online 1971）
卷期: Volume 4, issue 1  

页码: 41-52

 

ISSN:0003-2719

 

年代: 1971

 

DOI:10.1080/00032717108058589

 

出版商: Taylor & Francis Group

 

关键词: steroid;trimethylsilyl ether;enol ether;methoxime;urinary steroid;gas chromatography

 

数据来源: Taylor

 

摘要:

Highly hindered hydroxyl groups in steroids (17α-ol groups in steroids with a 17α, 20α, 21- or 17α,20β,21-triol structure) maybe converted to TMSi ether groups by reaction with N-trimethylsilylimidazole, alone or in combination withbis-trimethylsilylacetamide and with or without trimethylchlorosilane as a catalyst. At or above 150°C, the rates of catalyzed and non-catalyzed silylation reactions with these reagents are s imilar.

 

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