APOE-ε4 in Patients with Alzheimer Disease and Vascular Dementia
作者:
T A Treves,
N M Bornstein,
J Chapman,
S Klimovitzki,
R Verchovsky,
A Asherov,
I O Veshchev,
A D Korczyn,
期刊:
Alzheimer Disease and Associated Disorders
(OVID Available online 1996)
卷期:
Volume 10,
issue 4
页码: 189-191
ISSN:0893-0341
年代: 1996
出版商: OVID
关键词: APOE-ε4;Vascular dementia;Alzheimer disease;Primary degenerative dementia;Apolipoprotein;Epidemio
数据来源: OVID
摘要:
Summary:The apolipoprotein E (APOE) ε4 allele has been consistently found to be frequent in patients with progressive degenerative dementia of the Alzheimer type (DAT). Vascular dementia (VD) may occur as strokes superimposed on presymptomatic DAT, in which case APOE-ε4 frequency should also be increased in VD. We have examined the distribution of APOE-ε4 in patients with DAT (n = 176) or VD (n =74) and controls (n = 133), and evaluated the risk of dementia associated with APOE-ε4. APOE-ε4 allele frequency was 27% in DAT patients, 21% in VD patients, and 11% in controls. The difference in the distribution of the ε4 allele between DAT or VD patients and controls was statistically significant (χ2test, p < 0.05), with a 3.6- and 2.1-fold risk of dementia in DAT and VD patients carrying an ε 4 allele. The result that the APOE-ε4 allele is more frequent in DAT patients than in controls, with VD patients falling in between, is consistent with the assumption that VD is a heterogeneous condition, with some patients having an underlying preclinical brain degeneration, in whom the dementia was precipitated by strokes
点击下载:
PDF
(248KB)
返 回