This article presents findings of an exploratory descriptive study on the effects of dimethyl sulfoxide (DMSO) odor in an oncology unit. The nursing staff, who had reported their concerns about the unpleasant odor emitted from patients undergoing peripheral stem cell transplantation, initiated the study. A literature review revealed some evidence of the possible ill effects on staff caring for patients having DMSO treatment, but many questions remain unanswered such as what staff experience in dealing with DMSO odor and whether nursing care is affected in any way? Data were collected through interviews with 22 oncology nurses who all had experienced direct and indirect exposure to DMSO odor. Of the 22 nurses interviewed, 20 reported that they found DMSO odor unpleasant and reported experiencing physical symptoms such as headaches and gastrointestinal reactions. The study also revealed a situation in which nurses described odor avoidance and distancing strategies that potentially compromised the nurse–patient relationship.