Activation of Leukocytes During the Uteroplacental Passage in Preeclampsia
作者:
Jan,
Mellembakken Pål,
Aukrust Mette,
Olafsen Thor,
Ueland Kjetil,
Hestdal Vibeke,
期刊:
Hypertension: Journal of The American Heart Association
(OVID Available online 2002)
卷期:
Volume 39,
issue 1
页码: 155-160
ISSN:0194-911X
年代: 2002
出版商: OVID
关键词: preeclampsia;leukocytes;cell adhesion molecules;activation analysis
数据来源: OVID
摘要:
Endothelial dysfunction and inflammation appear to play a major role in the pathogenesis of preeclampsia. We hypothesize that a chronic inflammation in the decidua and placenta during preeclampsia may lead to a local leukocyte activation in this compartment. Venous blood was sampled simultaneously from antecubital and uterine veins during cesarean sections in 30 women with preeclampsia, 29 with uncomplicated pregnancies, and from 17 nonpregnant women. The expression of adhesion molecules and complement-related markers on neutrophils and monocytes was analyzed by flow cytometry. In patients with preeclampsia, neutrophil expression of the integrins CD11a, CD11b, and CD11c and of the complement related markers CD35 and CD59 was significantly higher in samples fromuterinethan fromantecubital veins. No differences were found in nonpregnant women. On monocytes the expression of the Sialyl Lewisxantigen, the integrins CD11a, CD11c, and CD49d, and the complement-related markers CD46 and CD59 was higher in samples fromuterinethan fromantecubital veinsduring preeclampsia, but not in uncomplicated pregnancies, whereas in nonpregnant women CD31 was decreased. Our findings suggest activation of neutrophils and monocytes taking place during the uteroplacental passage in preeclamptic, but not in normal pregnancies. Such a local inflammatory response involving enhanced leukocyte/endothelial interaction may contribute to the pathogenesis of this disorder.
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