Cocaine Use and Withdrawal: The Effect on Sleep and Mood
作者:
WatsonRobert,
BakosLinda,
ComptonPeggy,
GawinFrank,
期刊:
The American Journal of Drug and Alcohol Abuse
(Taylor Available online 1992)
卷期:
Volume 18,
issue 1
页码: 21-28
ISSN:0095-2990
年代: 1992
DOI:10.3109/00952999209001608
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractThree recreational cocaine users (age, 26.7 years), after one adaptation night, spent 5 days and nights in the laboratory where their EEG, EOG, and submental EMG were recorded during all of their sleep. On the second afternoon and evening of the study, subjects used an estimated 1 to 2 g cocaine intranasally. They all slept between 2:00 A.M. and 9:00 A.M. that night. Blood samples were drawn each evening and morning. Absolute plasma cocaine levels and patterns of elimination were consistent with subjects report of dose and time of administration. Mood ratings were made repeatedly throughout the study. There was suppression of REM sleep during the use of cocaine followed by a rebound which is specific to REM sleep and is not seen in other stages of sleep. REM variables subsided to normal levels on the third recovery night following cocaine use.
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