HPLC measurement of penticainide and desalkylpenticainide in biological fluids
作者:
S. Walker,
R. J. Flanagan,
D. W. Holt,
期刊:
Biomedical Chromatography
(WILEY Available online 1987)
卷期:
Volume 2,
issue 1
页码: 34-37
ISSN:0269-3879
年代: 1987
DOI:10.1002/bmc.1130020110
出版商: John Wiley&Sons, Ltd.
数据来源: WILEY
摘要:
AbstractA simple HPLC method has been developed to measure the antiarrhythmic agent penticainide and itsN‐desalkyl metabolite in biological fluids. Solvent extraction of a small (200 μL) sample volume with direct analysis of the extract is used to measure the plasma and urinary concentrations of these compounds attained during chronic therapy, although a larger sample volume (1.0 mL) and prior concentration of the extract are required for single oral dose work. In each case chromatographic analysis is performed using a microparticulate (5 μm) silica column and methanolic ammonium perchlorate (10 mM, pH 6.7) as eluent with UV detection (260 nm). No endogenous sources of interference have been encountered and potential interference from other drugs is mini
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