Minor chromosome variants in child psychiatric patients
作者:
Steve J. Funderburk,
Donald Guthrie,
Roger C. Lind,
Helga M. Muller,
Robert S. Sparkes,
Joan R. Westlake,
John M. Opitz,
期刊:
American Journal of Medical Genetics
(WILEY Available online 1978)
卷期:
Volume 1,
issue 3
页码: 301-308
ISSN:0148-7299
年代: 1978
DOI:10.1002/ajmg.1320010306
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: minor chromosome variants;heterochromatin;congenital disorders;mental retardation
数据来源: WILEY
摘要:
AbstractThe frequency of minor chromosome variants, as detected by conventional chromosome analysis, was examined among 1,289 child psychiatric patients, of whom one‐fourth had only behavioral problems and three‐fourths had congenital abnormalities and more severe mental disorders. There was no more than random association between prominent satellites, prominent secondary constrictions or a long Y chromosome, and congenital abnormalities or more severe mental disorders. The frequencies of these chromosome variants were affected by race as has been shown in previous studies. These findings do not support the evidence for a developmental effect of minor variants in
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