Newer antihypertensive drugs
作者:
James Gregoire,
Sheldon Sheps,
期刊:
Current Opinion in Cardiology
(OVID Available online 1995)
卷期:
Volume 10,
issue 5
页码: 445-449
ISSN:0268-4705
年代: 1995
出版商: OVID
数据来源: OVID
摘要:
We review three new classes of antihypertensive drugs: imidazolines, monatepil, and neutral endopeptidase inhibitors. Imidazolines are a new generation of central acting drugs. Because of their greater affinity for imidazoline receptors rather than (α2-adrenoreceptors, they cause less fatigue and dry mouth than the older central acting drugs. Monatepil is a single drug with both calcium antagonist and peripheral α1-antagonist properties. This agent not only lowers blood pressure but also lowers serum cholesterol, an effect mediated by its α-antagonism, and has anti-lipid peroxidation properties. Monatepil might become an effective antiatherosclerosis drug. Neutral endopeptidase inhibitors lower blood pressure by inhibiting the metabolism of atrial natriuretic peptide and other vasoactive peptides.
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