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Complement Split Products and the Pathogenesis of SLE

 

作者: AbramsonSteven B.,   WeissmannGerald,  

 

期刊: Hospital Practice  （Taylor Available online 1988）
卷期: Volume 23, issue 12  

页码: 45-56

 

ISSN:2154-8331

 

年代: 1988

 

DOI:10.1080/21548331.1988.11703590

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

Complement's role in SLE pathology is not limited to tissue damage at immune complex deposition sites. Circulating split products can cause inflammatory cells to occlude small vessels and damage their endothelium—all in the absence of IC deposition. In SLE, split-product levels reflect disease activity and predict flares better than conventional complement measurements.

 

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