Fibrinolytic Activity in Plasma after Gynecological and Urological Surgery
作者:
A. Aranda,
J.A. Paramo,
E. Rocha,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1988)
卷期:
Volume 18,
issue 2
页码: 129-134
ISSN:1424-8832
年代: 1988
DOI:10.1159/000215794
出版商: S. Karger AG
关键词: Thrombosis;deep vein;Fibrinolytic shut-down;postoperative;Plasminogen activator inhibitor;Surgery;gynecological and urological
数据来源: Karger
摘要:
Fibrinolytic activity was studied in 51 patients subjected to major surgery (27 urological and 24 gynecological) without prophylaxis. Postoperative deep-vein thrombosis (DVT) was diagnosed by venography in 6 patients (11 %). Blood samples were obtained preoperatively and on days 1, 3 and 7 postoperatively. Reduced fibrinolytic activity, as determined by prolongation of euglobulin lysis time (ELT), decrease in plasminogen activators on fibrin plate and decrease in tissue-type plasminogen activator (t-PA) activity were present postoperatively. Moreover, a marked increase in short duration in fast-acting inhibitor (PA-inhibitor) levels was observed on postoperative day 1 (p < 0.001). Patients with DVT had higher fibrinogen degradation product (FDP) levels on postoperative days 3 and 7 (p < 0.02). Preoperative PA-inhibitor activity was higher (p < 0.02) in those patients who developed postoperative DVT. It is concluded that the decrease in t-PA and the increase in PA-inhibitor may contribute to the reduced postoperative fibrinolytic activity after major surgery. PA-inhibitor may represent a useful predictive marker of postoperative DVT.
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