Synergistic Cytotoxicity of Recombinant Human TNF and Various Anti-Cancer Drugs
作者:
WatanabeNaoki,
NiitsuYoshiro,
YamauchiNaofumi,
OhtsukaYoshiki,
SoneHisao,
NedaHiroshi,
MaedaMasahiro,
UrushizakiIchiro,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1988)
卷期:
Volume 10,
issue 1
页码: 117-127
ISSN:0892-3973
年代: 1988
DOI:10.3109/08923978809014406
出版商: Taylor&Francis
关键词: Tumor necrosis factor (TNF);Anti-cancer drugs;The synergistic effect;In vitro
数据来源: Taylor
摘要:
AbstractA synergistic increase in the cytotoxic effects of recombinant human tumor necrosis factor (rH-TNF) and anti-cancer drugs was demonstrated in vitro. The cytotoxicity of rH-TNF against L-M cells in combination with Mitomycin C (MMC), Adriamycin (ADM), Cytosine arabinoside (Ara-C), Actinomycin D (ACD), Daunomycin (DM), Cisplatin (CDDP), Vincristin (VCR), and 5-Fluorouracil (5FU), based on the concentration necessary for 50% inhibition of cell growth (IC50), was 4 to 347 times as high as that of rH-TNF alone. The results suggest that combination therapy including rH-TNF and anti-cancer drugs may be of value in the treatment of malignancy in human patients.
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