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Synergistic Cytotoxicity of Recombinant Human TNF and Various Anti-Cancer Drugs

 

作者: WatanabeNaoki,   NiitsuYoshiro,   YamauchiNaofumi,   OhtsukaYoshiki,   SoneHisao,   NedaHiroshi,   MaedaMasahiro,   UrushizakiIchiro,  

 

期刊: Immunopharmacology and Immunotoxicology  (Taylor Available online 1988)
卷期: Volume 10, issue 1  

页码: 117-127

 

ISSN:0892-3973

 

年代: 1988

 

DOI:10.3109/08923978809014406

 

出版商: Taylor&Francis

 

关键词: Tumor necrosis factor (TNF);Anti-cancer drugs;The synergistic effect;In vitro

 

数据来源: Taylor

 

摘要:

AbstractA synergistic increase in the cytotoxic effects of recombinant human tumor necrosis factor (rH-TNF) and anti-cancer drugs was demonstrated in vitro. The cytotoxicity of rH-TNF against L-M cells in combination with Mitomycin C (MMC), Adriamycin (ADM), Cytosine arabinoside (Ara-C), Actinomycin D (ACD), Daunomycin (DM), Cisplatin (CDDP), Vincristin (VCR), and 5-Fluorouracil (5FU), based on the concentration necessary for 50% inhibition of cell growth (IC50), was 4 to 347 times as high as that of rH-TNF alone. The results suggest that combination therapy including rH-TNF and anti-cancer drugs may be of value in the treatment of malignancy in human patients.

 

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