Possible allelic association of a tyrosine hydroxylase polymorphism with vulnerability to alcohol‐withdrawal delirium
作者:
T. Sander,
H. Harms,
H. Rommelspacher,
M. Hoehe,
L. Schmidt,
期刊:
Psychiatric Genetics
(OVID Available online 1998)
卷期:
Volume 8,
issue 1
页码: 13-18
ISSN:0955-8829
年代: 1998
出版商: OVID
关键词: tyrosine hydroxylase gene;association study;candidate gene;alcohol dependenc;delirium
数据来源: OVID
摘要:
Recently, an association has been reported between schizophrenia and a rare allele containing 10-repeats (A10) of a polymorphic tetranucleotide motif in the first intron of the tyrosine hydroxylase (TH) gene. The present association analysis tested the hypothesis that the A10candidate allele confers vulnerability to alcohol-withdrawal delirium with visual hallucinations. The genotype of the TH tetranucleotide polymorphism was assessed in 204 German controls and 311 German alcohol-dependent subjects, including 63 alcoholics with a history of visual hallucinations during withdrawal delirium. The frequency of the A10allele was significantly increased in the alcoholics with withdrawal delirium (3.2%) compared with that in the controls (0.5%; Fisher's exact test:P= 0.03, two-tailed; OR(A10+) = 6.85, 95% confidence interval: 1.52–30.79). The possible allelic association suggests that allelic variation at the TH locus mediates vulnerability to alcohol-withdrawal delirium in a small proportion of alcohol-dependent subjects.
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