Application of Artificial Neural Network Multivariate Calibration to Near-Infrared Spectrophotometry Determination of Powdered Pharmaceutical Metronidazole
作者:
Yulin Ren,
Yuhui Gou,
Ruixue Ren,
Peiyi Liu,
Yie Guo,
期刊:
Spectroscopy Letters
(Taylor Available online 1999)
卷期:
Volume 32,
issue 3
页码: 431-442
ISSN:0038-7010
年代: 1999
DOI:10.1080/00387019909349996
出版商: Taylor & Francis Group
关键词: artificial neural network(ANN);Near infrared spectrophotometry;diffuse reflectance;the degree of approximation;overfilling;nondestructive;metronidazole powder
数据来源: Taylor
摘要:
The application of artificial neural networks for pharmaceutical quantitative analysis is described. Real data sets from near-infrared reflectance spectra of Metronidazole powdered pharmaceuticals were used to build an artificial neural network to predict unknown samples. A new network evaluation criterion, termed the degree of approximation, was employed. The overfitting was discussed. Owing to the beneficial nonlinear multivariate calibration nature of ANN. the predicted results were reliable and precise.
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