L‐Arginine reverses severe nephrosclerosis in aged spontaneously hypertensive rats
作者:
Hidehiko Ono,
Yuko Ono,
Edward Frohlich,
期刊:
Journal of Hypertension
(OVID Available online 1999)
卷期:
Volume 17,
issue 1
页码: 121-128
ISSN:0263-6352
年代: 1999
出版商: OVID
关键词: nephrosclerosis;hypertensive renal disease;aging;renal hemodynamics;proteinuria;endothelium;L-arginine
数据来源: OVID
摘要:
ObjectiveAcute and prolonged effects of L-arginine on systemic and renal hemodynamics and on renal pathological changes were examined in 85-week-old spontaneously hypertensive rats (SHR).ResultsAfter 3 weeks of L-arginine administration (n= 9; 2 g/l in drinking water), mean arterial pressure remained unchanged, although the cardiac index increased (187 ± 26 versus 263 ± 15 ml/min per kg;P< 0.05) and total peripheral resistance decreased (1.15 ± 0.18 versus 0.67 ± 0.06 AU;P< 0.05); the glomerular filtration rate increased (0.41 ± 0.07 versus 0.79 ± 0.07 ml/min;P< 0.01). Control untreated, aged SHR (n= 10) demonstrated severe nephrosclerosis histologically, but those treated with L-arginine demonstrated a markedly reduced glomerular injury score (164 ± 22 versus 83 ± 9;P< 0.005), and their urinary protein excretion (39 ± 5 versus 19 ± 5 mg/100 g body weight per day;P< 0.05) and serum creatinine concentration (1.4 ± 0.1 versus 0.9 ± 0.1 mg/dl;P< 0.05) diminished. Intravenous L-arginine (300 mg/kg body weight) given to untreated SHR reduced mean arterial pressure, increased the cardiac index (+98 versus +1%;P< 0.05) and decreased total peripheral resistance (+56 versus +13%,P< 0.005); however, these variables remained unchanged after 3 weeks of L-arginine treatment.ConclusionsThree weeks of treatment with L-arginine improved systemic hemodynamics, renal function and renal histologic changes in aged SHR with naturally occurring nephrosclerosis. These data provide an important insight into the pathophysiology of nephrosclerosis in hypertension and with aging, which is seen clinically.
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