Spectrophotometric Determination of Certain Local Anaesthetics in Pharmaceutical Preparations
作者:
G.A. Saleh,
H.F. Askal,
期刊:
Analytical Letters
(Taylor Available online 1995)
卷期:
Volume 28,
issue 15
页码: 2663-2671
ISSN:0003-2719
年代: 1995
DOI:10.1080/00032719508007417
出版商: Taylor & Francis Group
关键词: Spectrophotometry;Local anaesthetics;Haematoxylin
数据来源: Taylor
摘要:
A direct colorimetric method was described for the rapid, sensitive and accurate determination of dibucaine, lidocaine, bupivacaine, procaine and tetracaine in pharmaceutical preparations. The method involves the use of haematoxylin reagent in the presence of boric acid to give a reddish-violet chromogen (λmax= 555 nm). Beer's law was obeyed in the range from 2–60 μg/ml. No interference was observed from the commonly present additives or agents in pharmaceutical formulations.
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