Influence of the HDL receptor SR‐BI on atherosclerosis
作者:
Monty Krieger,
Karen Kozarsky,
期刊:
Current Opinion in Lipidology
(OVID Available online 1999)
卷期:
Volume 10,
issue 6
页码: 491-498
ISSN:0957-9672
年代: 1999
出版商: OVID
数据来源: OVID
摘要:
The scavenger receptor class B, type I (SR-BI) is an HDL receptor that mediates selective cholesterol uptake from HDL to cells. In rodents, SR-BI has a critical influence on plasma HDL-cholesterol concentration and structure, the delivery of cholesterol to steroidogenic tissues, female fertility, and biliary cholesterol concentration. SR-BI can also serve as a receptor for non-HDL lipoproteins and appears to play an important role in reverse cholesterol transport. Recent studies involving the manipulation of SR-BI expression in mice, either using adenovirus-mediated or transgenic hepatic overexpression or using homologous recombination for complete functional ablation, indicate that the expression of SR-BI protects against atherosclerosis. If SR-BI has a similar activity in humans, it may become an attractive target for therapeutic intervention.
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