Various natural and treated clays as well as some synthetic exchangers have been used to remove UO22+from aqueous solutions. Different factors which affect the adsorption process such as time, pH, competing ions … etc were studied. The mechanism of adsorption was found to be under film diffusion control. It was concluded that the naturally occuring clays are suitable as adsorbent for UO22+and their capacities are comparable, if not better than those treated clays or synthetic exchangers.