Images of acetylcholine receptor rich membrane fragments from the electric organ ofTorpedomarmorataobtained with STM and EM are compared as well as different methods of their preparation for the STM. The problem of identification of the observed structures is discussed, that means whether identification of observed structures could be accomplished by finding characteristic structures, selective adsorption and chemical markers such as toxins. Finally, we propose to use the tip not only for detection but also for preparation.