Monoamine Metabolites in Cerebrospinal Fluid and Behavioral Ratings in Patients with Early and Late Onset of Alzheimer Dementia
作者:
Görel Bråne,
C. Gottfries,
Kaj Blennow,
Ingvar Karlsson,
Annika Lekman,
Lucilla Parnetti,
Lars Svennerholm,
Anders Wallin,
期刊:
Alzheimer Disease and Associated Disorders
(OVID Available online 1989)
卷期:
Volume 3,
issue 3
页码: 148-156
ISSN:0893-0341
年代: 1989
出版商: OVID
关键词: Alzheimer dementia (AD/SDAT);CSF monoamine metabolites;Dementia ratings;GBS scale
数据来源: OVID
摘要:
Patients with Alzheimer disease (AD, onset <65 years of age, n = 13) and senile dementia of the Alzheimer type (SDAT, onset ≥65 years of age, n = 28) were investigated for cerebrospinal fluid (CSF) content of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA) and 3-methoxy-4-hydroxy-phenylglycol (MHPG) and compared with a group of controls (n = 26). A geriatric rating scale, the Gottfries-Bråne-Steen scale, was used to assess impairment of motor performance, intellectual and emotional functioning, and symptoms common in dementia disorders. The HVA levels in CSF were significantly lower in the AD group than in the SDAT group and controls. MHPG was slightly but significantly increased in the SDAT group when compared with the controls. The HVA and 5-HIAA concentrations were correlated negatively with impairment of motor performance in the SDAT group; 5-HIAA correlated positively with impaired performance in the AD group; and 5-HIAA/HVA ratios were correlated positively with the performance variables. HVA correlated significantly and negatively with “impaired wakefulness” and “inability to increase tempo” in the SDAT group. 5-HIAA and the ratio 5-HIAA/HVA correlated significantly and positively with some items measuring intellectual and emotional impairment. In the AD group, “anxiety” and “fear-panic” correlated positively with 5-HIAA and “restlessness” with MHPG. The data indicate qualitative differences in the CSF monoamine pattern between AD and SDAT.
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