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The effect of displacement from protein binding on serum and tissue fluid levels of cephazolin

 

作者: I. Polacek,   H. Mühlbauer,  

 

期刊: Biopharmaceutics&Drug Disposition  （WILEY Available online 1980）
卷期: Volume 1, issue 3  

页码: 127-132

 

ISSN:0142-2782

 

年代: 1980

 

DOI:10.1002/bdd.2510010307

 

出版商: John Wiley&Sons, Ltd.

 

关键词: Cephazolin;Sulphaphenazole;Protein binding;Displacement;Tissue fluid

 

数据来源: WILEY

 

摘要:

AbstractDisplacement of cephazolin, a highly protein‐bound β‐lactam antibiotic, by sulpha‐phenazole was studiedin vitroandin vivo. In vitro, the sulphonamide was effective in displacing the antibiotic from its binding sites at the concentration 100–1000 μmol I−1.In vivo, both the serum and the tissue fluid concentration of free cephazolin increased significantly in rats concomitantly treated with sulp

 

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