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Regression of “Hormone-Independent” DMBA-induced Mammary Carcinomas in Response to GP 48989 and its Effect on Hormone Receptors

 

作者: K.H. Schmidt-Ruppin,   U. Joss,   K. Schieweck,  

 

期刊: Oncology  （Karger Available online 1976）
卷期: Volume 33, issue 5-6  

页码: 229-231

 

ISSN:0030-2414

 

年代: 1976

 

DOI:10.1159/000225152

 

出版商: S. Karger AG

 

关键词: Thiazolidinone derivative GP 48 989;DMBA-induced mammary carcinomas;Hormone independent estrogen refractory;Estrogen receptor

 

数据来源: Karger

 

摘要:

GP 48 989 causes regression of DMBA-induced mammary carcinomas of spayed (“hormone-independent”), non spayed (∼5% “hormone-dependent”) rats and of tumors which had become refractory to estradiol treatment. Since no binding to the cytoplasmic estradiol receptor after prolonged intramuscular treatment was found, the compound does not act as a classical anti

 

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