Chemotherapy of advanced soft‐tissue sarcomas
作者:
Karen H. Antman,
Anthony D. Elias,
期刊:
Seminars in Surgical Oncology
(WILEY Available online 1988)
卷期:
Volume 4,
issue 1
页码: 53-58
ISSN:8756-0437
年代: 1988
DOI:10.1002/ssu.2980040111
出版商: John Wiley&Sons, Inc.
关键词: doxorubicin;ifosfamide;dacarbazine
数据来源: WILEY
摘要:
AbstractThe most active single agents in soft‐tissue sarcomas are doxorubicin (Adriamycin) and ifosfamide, with response rates of 20‐35%. Dacarba‐zine (DTIC) has a response rate of 16%. A randomized trial of 5 g/m2of ifosfamide versus 1.5 g/m2of cyclophosphamide noted a higher response rate for ifosfamide with less myelosuppression. Both randomized studies of doxorubicin with or without DTIC documented an increased response rate for the combination. In contrast, three randomized trials of doxorub‐icin‐based regimens with and without cyclophosphamide have failed to detect an advantage for the addition of cyclophosphamide. Thus, the most active combination for soft‐tissue sarcomas is doxorubicin and DTIC. The role of the addition of ifosfamide is currently under
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