Effects of Prostaglandin H2 on Perinatal Pulmonary Circulation
作者:
MARY TOD,
SIDNEY CASSIN,
DENNIS McNAMARA,
PHILIP KADOWITZ,
期刊:
Pediatric Research
(OVID Available online 1986)
卷期:
Volume 20,
issue 6
页码: 565-569
ISSN:0031-3998
年代: 1986
出版商: OVID
关键词: PG, prostaglandin;PVR, pulmonary vascular resistance;SAP, systemic arterial pressure;TX, thromboxane;PAP, pulmonary arterial pressure;LAP, left atrial pressure;Q, pulmonary arterial flow
数据来源: OVID
摘要:
A pivotal intermediate in prostaglandin (PG) biosynthesis is the endoperoxide PGH2. This endoperoxide is capable of eliciting direct responses in biological systems without undergoing conversion to other PGs. Effects of PGH2 include stimulation of platelet aggregation and vascular smooth muscle contraction in vitro; injections of PGH2 in vivo cause increases in pulmonary arterial pressure. The response of the pulmonary vasculature of perinatal lambs to PGH2 was measured using an in situ pumpperfused left lower lung preparation. Intrapulmonary injections of PGH2 (0.24-0.61 μg/kg) into six unventilated fetal lambs (0.93-0.97 gestation) produced decreases in pulmonary vascular resistance (PVR) of 10-21%. The fall in PVR was rapid in onset, reached a peak at 10 s after injection, and returned to baseline within 35S. Following ventilation (FIO2=0.21) of fetal lambs, injections of PGH2 (0.24-0.61 μg/kg) caused increases in PVR (ave increase=50% over control PVR). The pulmonary pressor re-sponse to PGH2 in ventilated fetal lambs was depressed almost 50% by inhibition of thromboxane synthetase. Injections of a “heat-inactivated” PGH2 did not affect PVR in ventilated fetuses. We did not observe any effects on systemic blood pressure or heart rate of intrapulmonary arterial injections of PGH2. These findings suggest a me-tabolism of PGH2 to dilator PGsbefore ventilation and constrictor PGsand thromboxanes after ventilation, and or direct effects of PGH2 on vascular smooth muscle that are dependent on existing vascular tone.
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