Genetics of neuronal migration in the cerebral cortex
作者:
Christopher A. Walsh,
期刊:
Mental Retardation and Developmental Disabilities Research Reviews
(WILEY Available online 2000)
卷期:
Volume 6,
issue 1
页码: 34-40
ISSN:1080-4013
年代: 2000
DOI:10.1002/(SICI)1098-2779(2000)6:1<34::AID-MRDD5>3.0.CO;2-Y
出版商: John Wiley&Sons, Inc.
关键词: neuronal migration;genetics;cell lineage
数据来源: WILEY
摘要:
AbstractThe development of the cerebral cortex requires large‐scale movement of neurons from areas of proliferation to areas of differentiation and adult function in the cortex proper, and the patterns of this neuronal migration are surprisingly complex. The migration of neurons is affected by several naturally occurring genetic defects in humans and mice; identification of the genes responsible for some of these conditions has recently yielded new insights into the mechanisms that regulate migration. Other key genes have been identified via the creation of induced mutations that can also cause dramatic disorders of neuronal migration. However, our understanding of the physiological and biochemical links between these genes is still relatively spotty. A number of molecules have also been studied in mice (Reelin, mDab1, and the VLDL and ApoE2 receptors) that appear to represent part of a coherent signaling pathway that regulates migration, because multiple genes cause an indistinguishable phenotype when mutated. On the other hand, two human genes that cause lissencephaly (LIS1,DCX) encode proteins that have recently been implicated as regulators or microtubule dynamics. This article reviews some of the mutant phenotypes in light of the mechanisms of neuronal migration. MRDD Research Reviews 6:34–40, 2000. © 2000 Wiley‐Lis
点击下载:
PDF
(138KB)
返 回