Preliminary studies on the inflammatory actions of the venoms of some Australian spiders
作者:
Natalie V. Korszniak,
David F. Story,
期刊:
Natural Toxins
(WILEY Available online 1995)
卷期:
Volume 3,
issue 1
页码: 21-25
ISSN:1056-9014
年代: 1995
DOI:10.1002/nt.2620030106
出版商: John Wiley&Sons, Inc.
关键词: Vascular permeability;Phonognatha graeffei;Badumna insignis;Isopeda montana;Delena cancerides;Lampona cylindrata;Steatodasp.
数据来源: WILEY
摘要:
AbstractExperiments were performed using an anaesthetised rat model to investigate the local inflammatory responses produced by intradermal injections of crude venom gland extracts from a number of Australian spiders, namely,Phonognatha graeffei, Delena cancerides, Isopeda montana, Badumna insignis, Lampona cylindrata, Steatoda grossa, S. capensisHann. All of the venom gland extracts tested, with the exception of that from S. capensis, produced increases in vascular permeability consistent with acute inflammatory responses. The responses primarily involved the activation of 5‐HT receptors, since they were markedly reduced by the nonselective 5‐HT1/5‐HT2‐receptor antagonist methiothepin. Some of the venoms caused liberation of endogenous mediators of inflammation, and some had components that acted directly on the vasculature to increase vascular permeability. Histamine appeared to have little if any role in the observed increases in vascular permeability following intradermal injection of the spider venoms. © 1995 Wiley
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